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KMID : 0364820140500030261
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Korean Journal of Microbiology
2014 Volume.50 No. 3 p.261 ~ p.263
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Peptide H Reduces IL-6 Expression in Human Breast Cancer MDA-MB-231 Cells
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Sung Dae-Il
Park Jam-Eon
Kim Han-Bok
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Abstract
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Chronic inflammation is involved in cancers, rheumatoid arthritis, and Crohn’s disease. Inerleukin-6 (IL-6) plays
major roles in inflammation. Chungkookjang, fermented soybean contains diverse peptides produced by cleavage of
soybean proteins. The peptides can be bioactive compounds. Peptide (Gly-Val-Tyr-Tyr-Met-Tyr was purified from
Chungkookjang, and modified to be 6mer H, Glu-Val-Tyr-Tyr-Met-Tyr (EVYYMY). Peptide H’s activity to suppress
IL-6 expression in a human breast cancer cell, MDA-MB-231 was determined. IL-6 Expression was reduced in the
cell treated with peptide H 25 times less than controls which were not treated with peptide H. Proliferation of
MDA-MB-231 cells was inhibited by peptide H, which is concentration-dependent. Blocking of IL-6 signals is
known to be effective in reducing inflammation in rheumatoid arthritis, Crohn’s disease, and cancers. Since peptide
H can reduce inflammatory IL-6 expression, application of this study will contribute to drug development for
diseases which are caused by excessive IL-6.
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KEYWORD
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breast cancer, IL-6, inflammation, peptide
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